Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques

Table 4

The outcomes of the rosuvastatin calcium equilibrium solubility in a mixture of two hydrotropic agents with a total concentration of 40%.

Combination	Total concentration (% W/V)	Individual concentration (% W/V)	Solubility, mg/ml	Solubility enhancement ratio
SS : U	40	20 : 20	77.62 ± 2.31	181.65
SS : C	40	20 : 20	32.48 ± 0.52	76.015
SS : M	40	20 : 20	54.98 ± 2.72	128.66
SS : SB	40	20 : 20	179.92 ± 40.05	421.02
SS : SB	40	5 : 35	81.10 ± 1.54	189.78
SS : SB	40	10 : 30	51.29 ± 3.38	120.01
SS : SB	40	15 : 25	166.40 ± 7.24	389.37

SS, sodium salicylate; U, urea; C, citric acid; M, mannitol; SB, sodium benzoate. The information is presented as the mean ± SD (n = 3).