Solubility Enhancement of a Poorly Water-Soluble Drug Using Hydrotropy and Mixed Hydrotropy-Based Solid Dispersion Techniques

Table 7

Saturated solubility data of rosuvastatin calcium in pure form and prepared formulations (rosuvastatin solid dispersion using freeze dryer (SDFD), rosuvastatin solid dispersion by rotary evaporator (SDRE), and rosuvastatin physical mixture (PM)).

SI no.	Formulation	Solubility, mg/ml	SER
1	ROS	0.427 ± 0.005	--------
2	SDRE	3.711 ± 0.166	8.690
3	SDFD	3.716 ± 0.316	8.703
4	PM	3.491 ± 0.03	8.177

ROS, pure rosuvastatin calcium; SER, solubility enhancement ratio.