Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs (Tristemma mauritianum and Crassocephalum bougheyanum) and One Tree (Lavigeria macrocarpa) Species
Table 8
Interactions of fluconazole with the plant extracts against yeast Candida isolates.
Yeast species
T. mauritianum (aerial parts)
L. macrocarpa (leaves)
C. bougheyanum (aerial parts)
FICA
FICB
∑FIC
Interpretation
FICA
FICB
∑FIC
Interpretation
FICA
FICB
∑FIC
Interpretation
Candida dubliniensis 5 : I52
0.25
0.25
0.5
Synergistic
0.125
<1
<2
Indifferent
0.062
0.062
0.124
Synergistic
Candida dubliniensis 1 : I59
<1
1
<2
Indifferent
<1
<1
<2
Indifferent
<1
1
<2
Indifferent
Candida dubliniensis 3 : I81
1
0.5
1.5
Indifferent
1
0.25
1.25
Indifferent
1
1
2
Indifferent
Candida albicans 7Ca
0.5
0.125
0.625
Additive
0.25
0.5
0.75
Additive
(0.5)
1
1.5
Additive
Candida albicans 11Ca
1
1
2
Indifferent
<1
<1
<2
Indifferent
<1
0.25
<2
Indifferent
Candida albicans 18Ca
0.5
0.25
0.75
Additive
0.125
0.25
0.375
Synergistic
1
0.25
1.25
Indifferent
Candida albicans Cppc BACT 017
0.25
0.25
0.5
Synergistic
0.25
0.25
0.5
Synergistic
1
1
2
Indifferent
Candida glabrata 11 : I81
<1
1
<2
Indifferent
<1
1
<2
Indifferent
<1
0.25
<2
Indifferent
Candida glabrata 10 : I39
1
1
2
Indifferent
(1)
1
2
Indifferent
0.25
0.25)
0.5
Synergistic
Candida tropicalis Cpc BACT 018
0.062
0.25
0.312
Synergistic
1
0.5
1.5
Additive
0.25
<1
<2
Indifferent
FICA: MIC of the fluconazole tested in combination/MIC of the fluconazole tested alone; FICB: MIC of the extract tested in combination/MIC of the extract tested alone; ∑FIC: FICA + FICE.
