Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Solubility medium</td><td class="align_center">Glyburide solubility (mcg/mL) ± SD</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Water</td><td class="align_center">11.67 ± 1.38</td></tr><tr><td class="align_left">Phosphate buffer (pH 7.8)</td><td class="align_center">21.19 ± 0.73</td></tr><tr><td class="align_left">Polymer solution in phosphate buffer</td><td class="align_center">107.00 ± 10.31</td></tr><tr><td class="align_left">Polymer and surfactant solution in phosphate buffer</td><td class="align_center">1544.54 ± 21.85</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Glyburide’s saturated solubility.</div>

Advances in Pharmacological and Pharmaceutical Sciences

tab2

Table 2

Table 2: Stability-Enhanced Ternary Solid Dispersions of Glyburide: Effect of Preparation Method on Physicochemical Properties 