Brazilin from Caesalpinia sappan L. as a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor: Pharmacophore-Based Virtual Screening, In Silico Molecular Docking, and In Vitro Studies

Table 1

Comparison of standard setting results with best optimization results.

The best feature pharmacophore	AUC100%	EF1%	EF5%	Sensitivity	Specificity
Default setting result	0.83	5.,0	12.0	0.857	0.309
Best optimization results	0.93	34.0	6.0	1.00	0.79