Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir

Table 1

Drug coformer miscibility calculation using Hildebrand and Hansen solubility parameter method.

S.no	Substance	Molecular weight (g/mol)	Density (g/cm^3)	Molecular volume (cm^3/mol)	Melting point (K)	Solubility parameter (MPa^1/2)
						Hildebrand	Hansen
							δd	δp	δh
1	Dolutegravir sodium	441.36	0.9	490.4	—	33.18	13.5	8.2	10.8
2	Dolutegravir	419.38	0.9	465.98	454.15	32.17	12.5	7.2	10.3
3	Soluplus	118000	1.20	98333	—	24.87	17.4	0.3	8.6