Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir

Table 2

Pharmacokinetic parameters after a single oral dose equivalent to 10 mg/kg of DS, DF, DSSD, and DFSD (n = 3).

S.no	Parameter	DS	DF	DFSD	DSSD
1	AUC0−t (μg·h/mL)	39.17 ± 5.16	51.17 ± 8.23	156.05 ± 10.15	128.29 ± 13.45
2	Cmax (μg/mL)	1.84 ± 3.50	3.58 ± 3.94	10.38 ± 20.77	7.42 ± 15.25
3	Tmax (hr)	6	6	2	6
4	t½ (hr)	13.91	12.69	11.43	14.33

^∗ indicates a significant difference when compared to DS and DF. ^∗p < 0.05 significantly different.