Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Figure 2

The 3D caption of native and known ligands with native ligand, and the 2D caption of native ligand and known ligands with amino acid residues. (a) = redocked native ligand 3D interaction with amino acid residues; (b) = native ligand 2D interaction with amino acid residues; (c) = docked known ligand (ZINC000043194322) 3D interaction with amino acid residues; (d) = known ligand (ZINC000043194322) 2D interaction with amino acid residues. Trp = tryptophan; Phe = phenylalanine; Asp = aspartic acid; Gln = glutamine; Met = methionine; Ser = serine; Ile = isoleucine; His = histidine; H = hydrogen; N = nitrogen; F = fluorine; O = oxygen; H₂O = water.