Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Figure 4

The 3D caption of chlorogenic acid and alpha-tocopherol with native ligand, and the 2D caption of chlorogenic acid and alpha-tocopherol with amino acid residues. (a) = chlorogenic acid 3D interaction with amino acid residues; (b) = chlorogenic acid 2D interaction with amino acid residues; (c) = alpha-tocopherol 3D interaction with amino acid residues; (d) = alpha-tocopherol (PubChem CID 1742129) 2D interaction with amino acid residues. Phe = phenylalanine; Asn = asparagine; Glu = glutamic acid; Asp = aspartic acid; Gln = glutamine; Met = methionine; Thr = threonine; Ile = isoleucine; Val = valine; His = histidine; H = hydrogen; O = oxygen; OH = hydroxyl group; H₂O = water.