Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies

Figure 6

Nonlinear regression curves between the activity (%) of nine tested samples against PDE4B1 and their concentrations (Log (µM)). (a) = sinigrin (IC50 = 0.24 ± 0.01 µM); (b) = white cabbage extract (IC50 = 0.27 ± 0.009 µM); (c) = quercetin (IC50 = 0.25 ± 0.01 µM); (d) = red onion extract (IC50 = 0.22 ± 0.02 µM); (e) = chlorogenic acid (IC50 = 0.20 ± 0.03 µM); (f)=coffee extract (IC50 = 0.18 ± 0.03 µM); (g) = combination (sinigrin, quercetin, and chlorogenic acid) standard (IC50 = 0.17 ± 0.03 µM); (h) = combination (white cabbage, red onion, and coffee) extract (IC50 = 0.12 ± 0.03 µM); (i) = rolipram (a PDE4B inhibitor) (IC50 = 0.15 ± 0.008 µM). PDE4B1 = phosphodiestrase-4B1; No Cpd = no compound.

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