Research Article
Structure Identification and Risk Assurance of Unknown Impurities in Pramipexole Oral Drug Formulation
Table 5
Incompatibility study of pramipexole and its excipients.
| | Sample ID | Condition | Unknown imp (RRT∼0.7) |
| | Pramipexole | W2 40°C | ND | | W4 40°C | ND |
| | Mixture of pramipexole + mannitol | W2 40°C | 0.04 | | W4 40°C | 0.38 |
| | Mixture of pramipexole + low hydroxypropyl cellulose | W2 40°C | ND | | W4 40°C | ND |
| | Mixture of pramipexole + colloidal anhydrous silica | W2 40°C | ND | | W4 40°C | ND |
| | Mixture of pramipexole + Mg stearate | W2 40°C | ND | | W4 40°C | ND |
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