Inhibition of Pancreatic Lipase by Flavonoid Derivatives: In Vitro and In Silico Investigations

Table 1

IC₅₀ values of flavonoid derivatives for pancreatic lipase.

Compounds	IC50 (µM)
F01	17.68 ± 1.43
F02	76.22 ± 3.22
F03	>>500
F04	>>500
F05	340.51 ± 24.10
F06	>>500
F07	>>500
F08	269.89 ± 14.55
F09	464.63 ± 11.76
F10	>>500
Orlistat	0.14 ± 0.00

The structures of flavonoid derivatives are presented in Figure 1. The studied compounds with the highest biological activity are highlighted in bold.