Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Figure 2

Antidepressant effect of imipramine (3–30 mgkg⁻¹) (a), fluoxetine (3–30 mgkg⁻¹) (b), venlafaxine (3–30 mgkg⁻¹) (c), xylopic acid (3–30 mgkg⁻¹) (d), and Xylopia aethiopica extract (30–300 mgkg⁻¹) (e) in tail-suspended mice. Black shaded bars represent mobility time, while grey shaded bars represent immobility time. , , , (two-way ANOVA). Data points are mean ± S.E.M. of n = 7 mice. Fluoxetine (FL), venlafaxine (VL), xylopic acid (XA), and Xylopia aethiopica extract (XAE).

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