Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Figure 6

Isobolograms for oral coadministration of Xylopia aethiopica extract with (a) imipramine, (b) fluoxetine, (c) venlafaxine in the tail suspension test. The theoretical ED₅₀ for an additive effect and the experimental ED₅₀ values are represented in the graphs.

(a)

(b)

(c)