Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 1

The potencies and peak effects of the various agents used in the tail suspension test.

Drugs	ED50 (mgkg^−1)	(%)
Xylopic acid	12.04 ± 2.92	72.99
Fluoxetine	14.21 ± 4.69	81.49
Venlafaxine	7.60 ± 2.42	97.43
Imipramine	16.57 ± 4.29	65.32
Xylopia aethiopica extract	148.60 ± 51.98	61.89