Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 2

Theoretical and experimental ED₅₀ ± S.E.M. of Xylopia aethiopica extract and antidepressant combinations in the tail suspension test and the corresponding computed indices.

Combinations	XAE/FL	XAE/VL	XAE/IP
Theoretical ED50 (mgkg^−1)	81.41 ± 26.10	78.10 ± 26.02	82.59 ± 26.08
Experimental ED50 (mgkg^−1)	40.83 ± 10.03	46.90 ± 11.18	26.62 ± 5.98
Interaction index (γ)	0.502	0.601	0.322
Drugs ratio	10.457 : 1	19.553 : 1	8.968 : 1

, , and (Student’s “t” test) compared experimental ED₅₀ to theoretical ED₅₀. Values are expressed as mean ± S.E.M.