Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 3

Theoretical and experimental ED₅₀ ± S.E.M. of xylopic acid and antidepressant combinations in the tail suspension test and the corresponding computed indices.

Combinations	XA/FL	XA/VL	XA/IP
Theoretical ED50 (mgkg^−1)	13.13 ± 2.76	9.82 ± 1.90	14.31 ± 2.59
Experimental ED50 (mgkg^−1)	3.91 ± 0.78	4.43 ± 1.08	7.95 ± 2.17
Interaction index (γ)	0.298	0.451	0.556
Drugs ratio	0.847 : 1	1.584 : 1	0.727 : 1

, , and (Student’s “t” test) compared experimental ED₅₀ to theoretical ED₅₀. Values are expressed as mean ± S.E.M.