Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 4

Effect of Xylopia aethiopica extract and xylopic acid on the pharmacokinetic disposition of imipramine.

Parameter	Unit	IP	IP/XA	IP/XAE
	h	44.38	50.48	18.22
	µg/ml	107.07 ± 5.55	74.59 ± 1.74	94.55 ± 0.75
	h	18	18	18
AUCo-t	µg/ml.h	1966 ± 58.98	1250 ± 55.95	1228 ± 67.40

, (Dunnett’s T3 multiple comparisons test) compared AUC of coadministrations to AUC of single-agent administration. Values are expressed as mean ± S.E.M (n = 5).