Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 5

Effect of Xylopia aethiopica extract and xylopic acid on the pharmacokinetic disposition of fluoxetine.

Parameter	Unit	FL	FL/XA	FL/XAE
	h	29.45	44.36	6.95
	µg/ml	100.71 ± 3.10	83.66 ± 6.39	118.33 ± 10.74
	h	12	12	12
AUCo-t	µg/ml.h	1783 ± 33.00	1577 ± 171.70	1278 ± 212.40

(Dunnett’s T3 multiple comparisons test) compared AUC of coadministrations to AUC of single-agent administration. Values are expressed as mean ± S.E.M (n = 5).