Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 6

Effect of Xylopia aethiopica extract and xylopic acid on the pharmacokinetic disposition of venlafaxine.

Parameter	Unit	VL	VL/XA	VL/XAE
	h	7.39	9.80	2.32
	µg/ml	71.43 ± 9.57	56.94 ± 23.88	45.54 ± 17.41
	h	18	12	12
AUCo–t	µg/ml.h	801.20 ± 105.40	870.70 ± 121.90	631.00 ± 82.14

(Dunnett’s T3 multiple comparisons test) compared AUC of coadministrations to AUC of single-agent administration. Values are expressed as mean ± S.E.M (n = 5).