Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants

Table 7

Effect of antidepressants on the pharmacokinetic disposition of xylopic acid.

Parameter	Unit	XA	IP/XA	VL/XA	FL/XA
	h	5.78	5.21	21.31	26.63
	µg/ml	81.94 ± 0.73	70.80 ± 8.84	17.30 ± 8.92	32.53 ± 1.58
	h	12	18	18	18
AUCo-t	µg/ml.h	968.10 ± 61.22	1079.00 ± 127.60	285.90 ± 51.92	510.60 ± 44.74

, , and (Dunnett’s T3 multiple comparisons test) compared AUC of coadministrations to AUC of single-agent administration. Values are expressed as mean ± S.E.M (n = 5).