Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites

Figure 1

The Shemin pathway. Eight enzymes (depicted in red) resident in three subcellular locations, including the apicoplast, cytosol, and mitochondrion, catalyse this reaction. The substrates and products are depicted in black. ALAS: 5-aminolevulinic synthase; ALAD: 5-aminolevulinic acid dehydratase; PBGD: porphobilinogen deaminase; UROS: uroporphyrinogen III synthase; UROD: uroporphyrinogen decarboxylase; CPO: coproporphyrinogen oxidase; PPO: protoporphyrinogen oxidase; FC: ferrochelatase.