Research Article
Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium
Table 1
Composition of PEG-g-poly (MAA) nanogels and calculation of sol–gel fraction.
| | Code | Ethylene glycol: MAA (mol) | Cross linker (% of total wt. of PEG + MAA) | Initiator (% of total wt. of PEG + MAA) | Wi (mg) | We (mg) | | |
| | N1 | 1:1 | 1 | 1 | 200 | 176 | 12 | 88 | | N2 | 2:1 | 1 | 1 | 200 | 162 | 19 | 81 | | N3 | 3 : 1 | 1 | 1 | 200 | 148 | 26 | 74 | | N4 | 1:2 | 1 | 1 | 200 | 181 | 9.5 | 90.5 | | N5 | 1:3 | 1 | 1 | 200 | 187 | 6.5 | 93.5 | | N6 | 1:4 | 1 | 1 | 200 | 191 | 4.4 | 95.5 | | N7 | 1:1 | 2 | 1 | 200 | 179 | 10.5 | 89.5 | | N8 | 1:1 | 3 | 1 | 200 | 186 | 7 | 93 | | N9 | 1:1 | 4 | 1 | 200 | 190.2 | 4.9 | 95.1 |
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