Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Table 5

Models of in-vitro drug release kinetics of PEG-g-poly (MAA) nanogels formulations with varying concentration of MAA.

Model	Parameters	N4		N5		N6
		pH 1.2	pH 6.8	pH 1.2	pH 6.8	pH 1.2	pH 6.8
Zero order		4.207	33.714	4.015	33.648	3.916	32.659
		0.6483	0.9085	0.6619	0.9220	0.7094	0.9237
First order		0.045	0.640	0.043	0.631	0.041	0.598
		0.6826	0.9736	0.6941	0.9693	0.7381	0.9756
Higuchi		6.386	49.800	6.090	49.572	5.922	48.145
		0.9731	0.9351	0.9711	0.9285	0.9792	0.9349
Korsmeyer Peppas		6.907	43.554	6.526	42.418	6.213	41.418
		0.9901	0.9634	0.9840	0.9648	0.9851	0.9691
		0.384	0.690	0.398	0.720	0.430	0.713