Development and In-Vitro Evaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

Table 7

Comparison between swelling of all formulation at pH 1.2 and pH 6.8.

Code	Varying pH	Mean ± SEM	p-value	Sig. difference
N1	Degree of swelling at pH 1.2	2.36069 ± 0.15	0.0012	Yes
	Degree of swelling at pH 6.8	8.5308 ± 0.93
N2	Degree of swelling at pH 1.2	2.41985 ± 0.15	0.0034	Yes
	Degree of swelling at pH 6.8	8.9151 ± 0.95
N3	Degree of swelling at pH 1.2	2.50485 ± 0.15	0.0031	Yes
	Degree of swelling at pH 6.8	9.3701 ± 0. 93
N4	Degree of swelling at pH 1.2	2.3103 ± 0. 15	0.0015	Yes
	Degree of swelling at pH 6.8	9.8958 ± 0.834
N5	Degree of swelling at pH 1.2	2.2695 ± 0. 15	0.0012	Yes
	Degree of swelling at pH 6.8	10.389 ± 0. 93
N6	Degree of swelling at pH 1.2	2.2109 ± 0. 15	0.0011	Yes
	Degree of swelling at pH 6.8	10.856 ± 0.829
N7	Degree of swelling at pH 1.2	2.3993 ± 0. 15	0.0013	Yes
	Degree of swelling at pH 6.8	8.0408 ± 0. 96
N8	Degree of swelling at pH 1.2	2.3023 ± 0. 15	0.0012	Yes
	Degree of swelling at pH 6.8	7.8608 ± 0. 94
N9	Degree of swelling at pH 1.2	2.2230 ± 0. 15	0.0011	Yes
	Degree of swelling at pH 6.8	7.6408 ± 0.857