Transcriptome Sequencing Reveals the Response to Acute Thermal Stress in the Pacific Abalone, Haliotis discus hannai

Table 3

Significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the hemolymph of Haliotis discus hannai under thermal stress.

Pathways	KO ID	Gene number	P-value
Thermal stress (6 hr)
Cysteine and methionine metabolism	KO00270	7	0.0058
FoxO signaling pathway	KO04068	7	0.0118
Antigen processing and presentation	KO04612	6	0.0177
MAPK signaling pathway	KO04010	9	0.0191
Flavonoid biosynthesis	KO00941	2	0.0200
Stilbenoid, diarylheptanoid, and gingerol biosynthesis	KO00945	2	0.0200
Protein processing in endoplasmic reticulum	KO04141	14	0.0210
Dorsoventral axis formation	KO04320	3	0.0225
Longevity regulating pathway	KO04211	6	0.0242
Adipocytokine signaling pathway	KO04920	4	0.0277
Thermal stress (24 hr)
Antigen processing and presentation	KO04612	8	0.0006
Estrogen signaling pathway	KO04915	8	0.0025
Tyrosine metabolism	KO00350	6	0.0031
Calcium signaling pathway	KO04020	8	0.0168
Protein processing in endoplasmic reticulum	KO04141	14	0.0191
Osteoclast differentiation	KO04380	3	0.0391
Phenylalanine metabolism	KO00360	2	0.0530
Sesquiterpenoid and triterpenoid biosynthesis	KO00909	2	0.0530
Styrene degradation	KO00643	2	0.0530
Necroptosis	KO04217	11	0.0628
Thermal stress (48 hr)
Estrogen signaling pathway	KO04915	7	0.0031
IL-17 signaling pathway	KO04657	4	0.0040
Antigen processing and presentation	KO04612	6	0.0055
Th17 cell differentiation	KO04659	3	0.0115
Adipocytokine signaling pathway	KO04920	4	0.0120
Osteoclast differentiation	KO04926	3	0.0211
Relaxin signaling pathway	KO04380	3	0.0211
Cysteine and methionine metabolism	KO00270	5	0.0331
T-cell receptor signaling pathway	KO04660	3	0.0339
B-cell receptor signaling pathway	KO04662	2	0.0343