The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial
Table 3
Mean systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, and rate pressure product in dexmedetomidine and control groups at baseline, during and after intubation.
(a)
Time
SBP (mmHg)
DBP (mmHg)
MAP (mmHg)
Dex group ()
Control group ()
value
Dex group ()
Control group ()
value
Dex group ()
Control group ()
value
Baseline
0.204
0.151
0.092
Before intubation
#
#
0.360
#
#
0.991
#
#
0.934
T0
#
#
0.004*
#
0.009*
#
#
0.012*
T1
#
0.068
#
0.099
#
0.058
T2
#
#
0.012*
#
#
0.005*
#
#
0.006*
T3
#
#
0.008*
#
0.002*
#
<0.001*
T4
#
#
0.013*
#
#
0.004*
#
#
0.002*
T5
#
#
0.017*
#
#
0.025*
#
#
0.008*
T6
#
#
0.028*
#
#
0.006*
#
#
0.005*
T7
#
#
0.012*
#
#
0.003*
#
#
0.003*
T8
#
#
0.003*
#
#
<0.001*
#
#
0.001*
T9
#
#
0.035*
#
#
0.005*
#
#
0.003*
T10
#
#
0.028*
#
#
0.004*
#
#
0.008*
(b)
Time
HR (beat per minute)
RPP (mmHg min−1)
Dex group ()
Control group ()
value
Dex group ()
Control group ()
value
Baseline
0.529
0.808
Before intubation
#
0.002*
#
#
0.106
T0
#
<0.001*
#
<0.001*
T1
#
<0.001*
#
0.003*
T2
#
0.001*
#
#
<0.001*
T3
#
<0.001*
#
<0.001*
T4
#
0.004*
#
0.002*
T5
0.007*
#
#
0.020*
T6
#
0.005*
#
#
0.002*
T7
#
0.007*
#
#
0.001*
T8
#
0.018*
#
#
<0.001*
T9
#
0.007*
#
#
0.001*
T10
#
0.011*
#
#
0.002*
Data are presented as mean ± SD. Dex group: dexmedetomidine group. SBP: systolic blood pressure. DBP: diastolic blood pressure. MAP: mean arterial pressure. HR: heart rate. RPP: rate pressure product. Baseline refers to the point of time before the study drug is administered. Before intubation refers to the point of time after anesthetic induction just before intubation. T0 is the period during intubation. T1–10 refer to minutes after intubation. * value < 0.05 compared between groups. # value < 0.05 compared to baseline values.