Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia

Table 2

Parameter estimates, along with their standard error and relative standard error, for the naïve pooled model and the population one-compartment model.

Parameter	Estimate	Standard error	Relative standard error
Naïve pooled model
Clearance (CL) (L/h/kg)	0.726	0.0253	0.0349
Volume of distribution (V) (L/kg)	7.90	1.05	0.133
Additive residual error (pg/mL)	109	6.86	0.0630
Population model
Clearance (CL) (L/h/kg)	0.697	0.0869	0.125
Volume of distribution (V) (L/kg)	7.48	1.17	0.157
Additive residual error (pg/mL)	94.3	8.83	0.0936
Between-subject variance on K	0.0394	0.116	2.95