Anesthesiology Research and Practice

Review Article

Effect of Ketamine/Propofol Admixture on Peri-Induction Hemodynamics: A Systematic Review and Meta-Analysis

Table 2

Trial and participant characteristics.


Author, year	Intervention -other adjuncts	Dose description	Patients	Female, (%)	Age, years (mean ± SD)	Weight, kg (mean ± SD) or median (range)	Care location	ASA class (%)

Abdalla, 2015 [27]	Ketamine/propofol admixture -Atracurium	Ketamine: 1 mg/kg Propofol: 2 mg/kg	30	46.6	38 ± 10.7	61.8 ± 9.7	Procedural suite	II: 80 III: 20
Abdalla, 2015 [27]	Dexmedetomidine + propofol -Atracurium	Dexmedetomidine: 1 mcg/kg Propofol: 2 mg/kg	30	33.3	42.7 ± 8.7	60.7 ± 8.5	Procedural suite	II: 86 III: 14

Aghdaii, 2015 [28]	Ketamine/propofol admixture -Sufentanil -Cisatracurium	Ketamine: 1 mg/kg Propofol: 1 mg/kg	50	30	57.36 ± 5.5	72.06 ± 8.7	OR	II: 60 III: 40
Aghdaii, 2015 [28]	Etomidate + midazolam -Sufentanil -Cisatracurium	Etomidate: 0.2 mg/kg Midazolam: 0.06 mg/kg	50	34	57.16 ± 5.6	71.28 ± 11.2	OR	II: 66 III: 34

Aydogan, 2014 [29]	Ketamine/propofol admixture	Ketamine: 100 mg Propofol: 100 mg	20	55	70 ± 65.83	67 (50–100)	OR	I: 45 II: 55
Aydogan, 2014 [29]	Propofol	Propofol: 200 mg	20	50	69 ± 65.83	68 (50–102)	OR	I: 50 II: 50

Baradari, 2017 [30]	Ketamine/propofol admixture -Fentanyl -Midazolam -Atracurium	Ketamine: 1 mg/kg Propofol: 1.5 mg/kg	41	39.02	58.71 ± 9.2	BMI: 26.85 ± 3.89	OR	I: 35 II: 65
Baradari, 2017 [30]	Etomidate + placebo -Fentanyl -Midazolam -Atracurium	Etomidate: 0.2 mg/kg Placebo: normal saline	40	30	62.23 ± 6.3	BMI: 25.23 ± 4.02	OR	I: 49 II: 51

Erdogan, 2013 [31]	Ketamine/propofol admixture -Fentanyl	Ketamine: 0.75 mg/kg Propofol: 0.75 mg/kg	40	0	71.67 ± 7.1	71.05 ± 9.37	OR	I: 30 II: 70
Erdogan, 2013 [31]	Propofol -Fentanyl	Propofol: 0.15 ml/kg (10 mg/ml)	40	0	70.85 ± 5.95	71.32 ± 9.58	OR	I: 35 II: 65

Hosseinzadeh, 2013 [32]	Ketamine/propofol admixture -Fentanyl -Midazolam -Atracurium	Ketamine: 0.75 mg/kg Propofol: 1 mg/kg	30	46.7	65.97 ± 9.31	73.48 ± 8.98	OR	I: 20 II:73.3 III: 6.7
Hosseinzadeh, 2013 [32]	Etomidate + propofol -Fentanyl -Midazolam -Atracurium	Etomidate: 0.2 mg/kg Propofol: 1 mg/kg	32	34.4	63.91 ± 10.05	72.00 ± 10.73	OR	I: 12.5 II: 68.8 III: 18.7

Iwata, 2009 [33]	Propofol + placebo -Fentanyl -Atropine -Vecuronium	Propofol: 2.0 mg/kg Placebo: normal saline	15	46.6	68 ± 10	58 ± 11	OR	N/R
	Ketamine/propofol admixture 0.5 -Fentanyl -Atropine -Vecuronium	Ketamine: 0.5 mg/kg Propofol: 2 mg/kg	15	46.6	69 ± 5	56 ± 10	OR	N/R
	Ketamine/propofol admixture 1.0 -Fentanyl -Atropine -Vecuronium	Ketamine: 1 mg/kg Propofol: 2 mg/kg	15	33.3	66 ± 10	56 ± 10	OR	N/R

Ozgul, 2013 [34]	Ketamine/propofol admixture -Remifentanil	Ketamine: 0.2 ml/kg (5 mg/ml) Propofol: 0.2 ml/kg (5 mg/ml)	40	45	37.75 ± 9.6	70.35 ± 12.42	OR	N/R
Ozgul, 2013 [34]	Propofol -Remifentanil	Propofol: 0.2 ml/kg (10 mg/ml)	40	57.5	41.47 ± 12.86	73.52 ± 12.61	OR	N/R

Smischney, 2012 [11]	Ketamine/propofol admixture -Fentanyl -Midazolam	Ketamine: 0.75 mg/kg Propofol: 1.5 mg/kg	41	65	42 ± 12	68.9 ± 11.2	OR	I: 35 II: 65
Smischney, 2012 [11]	Propofol -Fentanyl -Midazolam	Propofol: 2 mg/kg	43	65	43 ± 11	69.2 ± 11.7	OR	I: 49 II: 51

Vora, 2005 [35]	Ketamine/propofol admixture -Fentanyl -Midazolam	Ketamine: 50 mg Propofol: 100 mg	30	33.3	42 ± 7.05	49.4 ± 11.7	Procedural suite	I-II: 100
	Propofol + thiopentone -Fentanyl -Midazolam	Propofol: 100 mg Thiopentone: 125 mg	30	43.3	40.05 ± 9.28	53.6 ± 10.4	Procedural suite
	Propofol + lignocaine -Fentanyl -Midazolam	Propofol: 190 mg Lignocaine: 20 mg	30	30	39.6 ± 11.9	51 ± 9.52	Procedural suite

ASA: American Society of Anesthesiologists; BMI: body mass index; kg: kilograms; mcg: micrograms; mg: milligrams; ml: milliliters; N/R: not reported; OR: operating room; SD: standard deviation.