Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study

Table 5

Comparison according to postoperative sedation, side effects, and satisfaction.

Variables		Ketamine (N = 30)	Control (N = 30)	value	Effect of ketamine relative to control
					Mean ± SD	95% CI
Postoperative sedation
Minute 0		1.3 ± 0.5	0.3 ± 0.5	^∧<0.001	1.0 ± 0.1	0.8–1.2
Minute 60		0.2 ± 0.4	0.0 ± 0.0	^∧0.023	0.2 ± 0.1	0.0–0.3
Minute 120		0.1 ± 0.3	0.0 ± 0.0	^∧0.155	0.1 ± 0.0	0.0–0.2
Satisfaction
Satisfaction		1.6 ± 0.5	2.8 ± 0.8	^∧<0.001	-1.2 ± 0.2	−1.5–0.8
Perioperative side effects
					RR (95% CI)
Headache	Intraoperative	6 (20.0%)	0 (0.0%)	§0.024	—
	Postoperative	7 (23.3%)	6 (20.0%)	#0.754	1.17 (0.44–3.07)
Diplopia	Intraoperative	9 (30.0%)	0 (0.0%)	§0.002	—
	Postoperative	6 (20.0%)	0 (0.0%)	§0.024	—
Perioperative psychedelic phenomena
Hallucination		2 (6.7%)	0 (0.0%)	§0.492	—
Dissociation		6 (20.0%)	0 (0.0%)	§0.024	—
Relaxation		25 (83.3%)	0 (0.0%)	#<0.001	—
Euphoria		7 (23.3%)	0 (0.0%)	§0.011	—
Dysphoria		1 (3.3%)	0 (0.0%)	§0.999	—

^∧Independent t-test. #Chi square test. §Fisher’s Exact test. Significant. RR: relative risk. CI: confidence interval. Significant.