Hemodynamic Effects of Methamphetamine and General Anesthesia
Table 1
Demographic summary.
No meth (n = 159)
Subacute positive (n = 69)
Acute positive (n = 137)
value
Sex
Female
45 (28.3%)
12 (17.4%)
24 (17.5%)
0.048
Male
114 (71.7%)
57 (82.6%)
113 (82.5%)
Age
33.7 ± 11.4
36.1 ± 10.4
38.3 ± 11.5
0.002
Age group
Age 16 to 30
74 (46.5%)
22 (31.9%)
41 (29.9%)
0.004
Age 31 to 40
43 (27%)
24 (34.8%)
37 (27%)
Age 41 to 50
27 (17%)
16 (23.2%)
38 (27.7%)
Age 51 to 60
15 (9.4%)
7 (10.1%)
14 (10.2%)
Age >61
0 (0%)
0 (0%)
7 (5.1%)
Modified ASA
1
27 (17%)
6 (8.7%)
6 (4.4%)
0.002
2
132 (83%)
63 (91.3%)
131 (95.6%)
Surgery performed
GI
0 (0%)
1 (1.5%)
1 (0.7%)
Not applicable
GYN
0 (0%)
0 (0%)
1 (0.7%)
General surgery
26 (17.2%)
10 (14.7%)
14 (10.4%)
OMFS
16 (10.6%)
7 (10.3%)
3 (2.2%)
Ophtho
0 (0%)
0 (0%)
1 (0.7%)
Ortho
107 (70.9%)
50 (73.5%)
113 (83.7%)
Podiatry
1 (0.7%)
0 (0%)
0 (0%)
Urology
1 (0.7%)
0 (0%)
2 (1.5%)
Inhaled agent
Isoflurane
0 (0%)
1 (1.5%)
0 (0%)
Not applicable
Sevoflurane
159 (100%)
68 (98.6%)
136 (100%)
Not applicable
N2O status
Did not receive N2O
86 (54.1%)
38 (55.1%)
84 (61.3%)
0.429
Received N2O
73 (45.9%)
31 (44.9%)
53 (38.7%)
Phenylephrine dose mcg
216 ± 200
527 ± 614
568 ± 653
0.003
Ephedrine dose mg
8.6 ± 4.1
14.3 ± 10.1
29.2 ± 28.8
0.016
Epinephrine dose mcg†
Not applicable
Not applicable
102 ± 139
Not applicable
Vasopressin dose units†
Not applicable
Not applicable
5 ± 1
Not applicable
Average sevoflurane/isoflurane concentration %
2 ± 0.5
1.9 ± 0.8
1.9 ± 0.6
0.175
Average N2O concentration % (patients who received N2O)
51.3 ± 3.3
50 ± 0
50.9 ± 5.1
0.447
Propofol dose mg/kg
2.5 ± 0.7
2.7 ± 0.9
2.3 ± 0.6
0.001
Fentanyl dose mcg/kg
185 ± 65
182 ± 74
177 ± 63
0.549
Dilaudid dose mg/kg (all patients)
0.0374 ± 0.0056
0.00171 ± 0.105
0.00395 ± 0.0069
0.093
Dilaudid dose mg/kg (patents who received dilaudid)
0.0091 ± 0.0054
0.0422 ± 0.1643
0.0120 ± 0.0070
0.119
Morphine dose mg/kg
0 ± 0
0 ± 0
0 ± 0
0.135
Zero patients in control and only two patients in each of the investigation groups receive morphine. †Zero patients in control and subacute groups received vasopressin or epinephrine.
