Research Article

DU Is Induced by Low Levels of Urinary ATP in a Rat Model of Partial Bladder Outlet Obstruction: The Incidence of Both Events Decreases after Deobstruction

Figure 3

Typical cystometrograms of DU animals after stimulation with ACh and ATP. Images of a typical cystometrogram of one of the six animals that did not present bladder contraction (voided by overflow) and received (a) a topical application of 1 µM of ACh in the serosa. In this cystometrogram, the single application of ACh (red arrow) generated an immediate voiding contraction. (b) After washout, the same animal intravesical received 5 mg/kg of ATP (red arrow), resulting in voiding contractions.
(a)
(b)