Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model

Figure 2

Wild-type EBOV nonlethal infection in guinea pigs. Electron microscopy of the liver.

(a) Activated macrophage (MP) with phagosomes and polymorphous virus particles (Vpt) in the necrotic focus of the liver. Day 1 p/i

(b) Necrotic focus in the liver, day 5 p/i. Arrows show the virus replication centers in the cell debris

(c) Cell fragment with osmiophilic inclusions (arrows), virus particles (Vpt), and viroplasm (Vpl) in the nucleus. Day 7 p/i