The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex

Figure 3

Histopathological findings in the lung and kidney tissue (H&E). (a) Lung tissue section treated with normal saline 0.9% as control showed normal histology of the lung consisting of alveoli surrounded by normal alveolar septae and no inflammatory cell infiltration. (b) Lung section of LPS-injected group C showed alveolar hemorrhage and pretentious material (red arrow), interstitial inflammatory cell infiltration, and diffuse alveolar damage (green arrow) (score 3 tissue damage). (c) Lung tissue section of LPS-injected and quercetin complex-treated group B showed reduced inflammatory cell infiltration in some areas and focal dispersed destruction of alveolar (score 1 tissue damage). (d) The tissue section of the kidney treated with normal saline 0.9% of the control group (group A) showed normal histological appearance, consisting of glomeruli, proximal and distal convoluted tubules, and no interstitial inflammatory cell infiltration. (e) Renal section of LPS-injected group C showed dilated glomerular capillaries (red arrow), congested blood vessels, damage of renal tubules with the presence of hyaline cast inside renal tubules (yellow arrow), and focal inflammatory cell infiltration (black arrow) (score 4 tissue damage). (f) Kidney tissue section of LPS-injected and quercetin complex-treated group B showed only mild degenerative changes of epithelial renal tubules (score 1 tissue damage).