Research Article
Therapeutic Promises of Plant Metabolites against Monkeypox Virus: An In Silico Study
Table 3
Toxicity properties analysis of screened drug candidates.
| | Toxicity properties | Curcumin | Gedunin | Piperine | Coumadin |
| | AMES toxicity | − | − | − | − | | Maximum tolerated human dose | 0.081 | −0.736 | −0.38 | 0.294 | | hERG I inhibitor | − | − | − | − | | hERG II inhibitor | − | − | − | − | | Oral rat Acute toxicity at LD50 (mg/kg_bw/day) | 1.833 | 2.998 | 2.811 | 1.773 | | Oral rat chronic toxicity at LOAEL | 2.228 | 0.195 | 1.51 | 1.081 | | Hepatotoxicity | − | − | + | − | | Skin sensitisation | − | − | − | − | | Toxicity in T. pyriformis | 0.494 | 0.291 | 1.879 | 0.591 | | Minnow toxicity | −0.081 | 0.456 | 1.732 | 0.034 |
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