Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

Chaudhary, Ashu; Singh, Ran Vir

doi:https://doi.org/10.1155/BCA/2006/17316

Bioinorganic Chemistry and Applications

On this page

Abstract References Copyright Related Articles

Open Access

Volume 2006 | Article ID 017316 | https://doi.org/10.1155/BCA/2006/17316

Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

Ashu Chaudhary¹and Ran Vir Singh¹

Received12 Aug 2004

Revised18 Oct 2004

Accepted25 Nov 2004

Published21 May 2006

Abstract

Antifertility and histopathological investigations were carried out on reproductive organs of male albino rats induced by tetraazamacrocyclic complexes of iron(II). The complexes were synthesized by the template condensation of 1,2-diaminoethane, 1,3-diaminopropane with succinic acid and phthalic acid in 2:2 molar ratios which are abbreviated as [Fe(TAMLn)OAc] (n=1 or 2 and TAMLn represents tetraazamacrocyclic ligand). The complexes have been characterized by elemental analysis, conductivity measurements, IR, and electronic spectra.

References

D S Bhakuni, M L Dhar, M M Dhar, B N Dhawan, and B N Mehrotra, “Screening of Indian plants for biological activity. II,” Indian Journal of Experimental Biology, vol. 7, no. 4, pp. 250–262, 1969.
View at: Google Scholar
S K Dixit and G K Bhatt, “Folk-lore studies on unknown indigenous antifertility drugs,” The Journal of Research in Indian Medicine, vol. 10, no. 3, pp. 77–81, 1975.
View at: Google Scholar
B N Dhawan, G K Patnaik, R P Rastogi, K K Singh, and J S Tandon, “Screening of Indian plants for biological activity: part VI,” Indian Journal of Experimental Biology, vol. 15, no. 3, pp. 208–219, 1977.
View at: Google Scholar
R Kamal, R Yadav, and J D Sharma, “Efficacy of the steroidal fraction of fenugreek seed extract on fertility of male albino rats,” Phytotherapy Research, vol. 7, no. 2, pp. 134–138, 1993.
View at: Google Scholar
S Sharma, R K Sharma, R Sharma et al., “Synthesis and characterisation of some new aluminium derivatives of Schiff bases containing N, O and S donor atoms and the anti fertility activity of the derivative ${\text{Al}}[{\text{SC}}_6 {\text{H}}_4 {\text{N}}$ : ${\text{C}}({\text{CH}}_3 ){\text{CH}}_2 {\text{COCH}}_3 ]_3$ ,” Bioinorganic Chemistry and Applications, vol. 1, no. 3-4, pp. 215–225, 2003.
View at: Google Scholar
C Saxena, R V Singh, and S C Joshi, “Spectroscopic characterization and in vitro and in vivo screening of difluoro-boron complexes,” Bulletin of the Chemical Society of Japan, vol. 67, pp. 1007–1010, 1994.
View at: Google Scholar
K Sharma, S C Joshi, and R V Singh, “Fertility inhibitor heterobimetallic complexes of platinum(II) and palladium(II): synthetic, spectroscopic and antimicrobial aspects,” Metal-Based Drugs, vol. 7, no. 2, pp. 105–113, 2000.
View at: Google Scholar
M Jain, S Gaur, S C Diwedi, S C Joshi, R V Singh, and A Bansal, “Nematicidal, insecticidal, antifertility, antifungal and antibacterial activities of salicylanilide sulphathiazole and its manganese, silicon and tin complexes,” Phosphorus, Sulfur, and Silicon and the Related Elements, vol. 179, no. 8, pp. 1517–1537, 2004.
View at: Google Scholar
R V Singh, R Dwivedi, and S C Joshi, “Synthetic, magnetic, spectral, antimicrobial and antifertility studies of dioxomolybdenum(VI) unsymmetrical imine complexes having a {N\!\raisebox{5pt}{$\frown$}\!N} donor system,” Transition Metal Chemistry, vol. 29, no. 1, pp. 70–74, 2004.
View at: Google Scholar
N Fahmi, A Bansal, S C Joshi, and R V Singh, “Effects of manganese(II) complexes of [2-1-thienyl)ethylidene] hydrazinecarbo-thioamide on reproductive function of male rats,” Asian Journal of Chemistry, vol. 11, pp. 1488–1496, 1999.
View at: Google Scholar
K D Karlin and J Zubieta, Eds., Copper Coordination Chemistry: Biochemical and Inorganic Perspectives, vol. 113, Adenine Press, New York, NY, 1983.
M RN Prasad, N J Chinoy, and K M Kadam, “Changes in succinic dehydrogenase levels in the rat epididymis under normal and altered physiologic conditions,” Fertility and Sterility, vol. 23, no. 3, pp. 186–190, 1972.
View at: Google Scholar
O H Lowry, N J Rosebrough, A L Farr, and R J Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951.
View at: Google Scholar
L Warren, “The thiobarbituric acid assay of sialic acids,” The Journal of Biological Chemistry, vol. 234, no. 8, pp. 1971–1975, 1959.
View at: Google Scholar
A Zlatkis, B Zak, and A J Boyle, “A new method for the direct determination of serum cholesterol,” The Journal of Laboratory and Clinical Medicine, vol. 41, no. 3, pp. 486–492, 1953.
View at: Google Scholar
R Montgomery, “Determination glycogen,” Archives of Biochemistry and Biophysics, vol. 67, no. 2, pp. 378–386, 1957.
View at: Google Scholar
D Foreman, L Gaylor, E Evans, and C Trella, “A modification of the Roe procedure for determination of fructose in tissues with increased specificity,” Analytical Biochemistry, vol. 56, no. 2, pp. 584–590, 1973.
View at: Google Scholar
J H Roe and C A Kuether, “The determination of ascorbic acid in whole blood and urine through the 2,4-dinitrophenylhydrazine derivative of dehydroascorbic acid,” The Journal of Biological Chemistry, vol. 147, no. 2, pp. 399–407, 1943.
View at: Google Scholar
C MH Fiske and Y Subbarow, Practical Physiological Chemistry, McGraw-Hill, New York, NY, 4th edition, 1965.
K K Nanda, S K Dutta, and B Adhikary, “Synthesis and characterization of teteranuclear nickel(II) complex with a macrocyclic ligand,” Indian Journal of Chemistry, vol. 34A, pp. 64–73, 1995.
View at: Google Scholar
M Malon, Z Travnicek, M Marysko et al., “Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with ${\text{N}}^6$ -benzylaminopurine derivatives,” Inorganica Chimica Acta, vol. 323, no. 1-2, pp. 119–129, 2001.
View at: Google Scholar
T S Lobana, H S Cheema, and S S Sandhu, “Chemistry of iron complexes—IV. Spectroscopic, magnetic and other properties of complexes of iron(II) iodide and iron(II) tetracarbonyl iodide with b,” Polyhedron, vol. 4, no. 4, pp. 717–721, 1985.
View at: Google Scholar
A Chaudhary, D P Jaroli, and R V Singh, “Antimicrobial, antifertility and antiinflammatory approach to tetradentate macrocyclic complexes of iron(II) and manganese (II),” Metal-Based Drugs, vol. 8, no. 6, pp. 347–353, 2001.
View at: Google Scholar
N J Chinoy and M R Chinoy, “Effects of chronic administration of aluminium chloride on reproduction of the testes and some accessory sex organs of male rats,” J. Reproductive Biology Comp. Endocrinology, vol. 2, no. 1, pp. 1–9, 1982.
View at: Google Scholar
R S Gupta, A K Bhatnager, Y C Joshi, R Sharma, and A Sharma, “Suppression of fertility in male albino rats following $\alpha$ -amyrin acetate administration,” Pharmaceutical Biology, vol. 42, no. 2, pp. 98–104, 2004.
View at: Google Scholar
M P Dobhal, A S Shabbir, P Pranvir, and R S Gupta, “Biologically active constituents isolated from medicinal plants,” Himalayan Chemical and Pharmaceutical Bulletin, vol. 17, pp. 22–26, 2000.
View at: Google Scholar
P Mathur, D K Vyas, N Sharma, and D Jacod, “Abstract,” in International Symposium on Male Contraception: Present and Future, p. 27, New Delhi, India, November 1995.
View at: Google Scholar
G Gupta, M Rajalakshmi, M RN Prasad, and N R Moudgal, “Alteration of epididymal function and its relation to maturation of spermatozoa,” Andrologia, vol. 6, no. 1, pp. 35–44, 1974.
View at: Google Scholar
D A Bhiwgade, S N Menon, and K M Avari, “Effect of cyproterone acetate on testis of albino rats: ultrastructural and biochemical approach,” Indian Journal of Experimental Biology, vol. 28, no. 3, pp. 201–207, 1990.
View at: Google Scholar
N Sharma and D Jacob, “Fertility suppression of the male mouse after administration of mint leaf extract,” Phytotherapy Research, vol. 10, no. 2, pp. 175–177, 1996.
View at: Google Scholar
G David, P Jouannet, A Martin-Boyce, A Spira, and D Schwartz, “Sperm counts in fertile and infertile men,” Fertility and Sterility, vol. 31, no. 4, pp. 453–455, 1979.
View at: Google Scholar
M V Rao, F Thakor, G Shiney, K D Shah, and G K Roy, “Contraceptive efficacy of testosterone enanthate in males,” Journal of Animal Morphology and Physiology, vol. 43, no. 1, pp. 15–21, 1996.
View at: Google Scholar
R D Amelar, L Dubin, and C Schoenfeld, “Sperm motility,” Fertility and Sterility, vol. 34, no. 3, pp. 197–215, 1980.
View at: Google Scholar
Gupta RS , R Sharma, A Sharma et al., “Antispermatogenic effect and chemical investigation of Opuntia dillenii,” Pharmaceutical Biology, vol. 40, no. 6, pp. 411–415, 2002.
View at: Google Scholar
H L Watson, M K Davidson, N R Cox, J K Davis, K Dybvig, and G H Cassell, “Protein variability among strains of mycoplasma pulmonis,” Infection and Immunity, vol. 55, no. 11, pp. 2838–2840, 1987.
View at: Google Scholar
R Jones, “Effects of testosterone, testosterone metabolites and anti-androgens on the function of the male accessory glands in the rabbit and rat,” Journal of Endocrinology, vol. 74, no. 1, pp. 75–88, 1977.
View at: Google Scholar
P C Mali, M Chaturvedi, and V P Dixit, “Antispermatogenic activity of Solanum xanthocarpum S and W root (50 percent EtOH extract) in rats,” Journal of Phytological Research, vol. 9, no. 1, pp. 13–17, 1996.
View at: Google Scholar
S Nag, D Sarkar, and J J Ghosh, “Sialic acid & sialidase activity in rat testis & epididymis in relation to age & action of different antifertility agents,” Indian Journal of Experimental Biology, vol. 15, no. 7, pp. 510–512, 1977.
View at: Google Scholar
D R Gupta and B Ahmed, “Emarginatosides B and C: Two new saponins from Sapindus emarginatus fruits,” Indian Journal of Chemistry, vol. 29B, pp. 268–270, 1991.
View at: Google Scholar
S K Bhargava, “Anti-spermatogenic activity of malvidin chloride in langur monkeys (Presbytis entellus entellus Dufresne),” International Journal of Andrology, vol. 13, no. 3, pp. 207–215, 1990.
View at: Google Scholar
S K Gupta, “Current status of development and clinical testing of male intravasal contraceptives (Abstr.),” in International Symposium on Male Contraception: Present and Future, p. 6, New Delhi, India, November 1995.
View at: Google Scholar
N M Biswas and C Deb, “Testicular degeneration in rats during hypervitaminosis A,” Endokrinologie, vol. 49, no. 1, pp. 64–69, 1965.
View at: Google Scholar
A D Johnson, “Testicular lipids,” in The Testis, A D Johnson, W R Gomes, and N L Van Demark, Eds., vol. 2, Academic Press, New York, NY, 1967.
View at: Google Scholar
S K Garg, V S Mathur, and R R Chaudhury, “Screening of Indian plants for antifertility activity,” Indian Journal of Experimental Biology, vol. 16, no. 10, pp. 1077–1079, 1978.
View at: Google Scholar
N J Chinoy and D Mehta, “Beneficial effects of the amino acids glycine and glutamine on testis of mice treated with sodium fluoride,” Fluoride, vol. 32, no. 3, pp. 162–170, 1999.
View at: Google Scholar
L L Ewing, A R Means, C G Jr Beames, and R D Montgomery, “Biochemical changes in rat testis during postnatal maturation,” Journal of Reproduction and Fertility, vol. 12, no. 2, pp. 295–307, 1966.
View at: Google Scholar
A Chaterjee, P Adhikari, J Benerji, C Choudhury, S Jana, and A Sen Gupta, “Antifertility effect of Piper beetle Linn. (Stalk) in adult male rats,” Journal of the Indian Chemical Society, vol. 71, pp. 81–84, 1994.
View at: Google Scholar
M M Sharma, G Lal, and D Jacob, “Effects of low doses of chlormadinone acetate in the rat,” Journal of Reproduction and Fertility, vol. 48, no. 1, pp. 177–179, 1976.
View at: Google Scholar

Copyright

Copyright © 2006 Ashu Chaudhary and Ran Vir Singh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation Order printed copies