Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Shanker, D.; Rai, A. K.; Singh, Y. P.; Rehwani, H.; Khushalani, V.; Gupta, R. S.

doi:https://doi.org/10.1155/BCA/2006/20979

Bioinorganic Chemistry and Applications

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Volume 2006 | Article ID 020979 | https://doi.org/10.1155/BCA/2006/20979

Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

D. Shanker,¹A. K. Rai,¹Y. P. Singh,¹H. Rehwani,²V. Khushalani,²and R. S. Gupta²

Received24 Sept 2004

Revised05 Feb 2005

Accepted01 Mar 2005

Published04 Apr 2006

Abstract

Benzothiazoline HNC6H4SC︹(C6H5)CH:C(OH)COOCH3 1 prepared by the condensation reaction of aroyl pyruvate and 2-aminothiophenol has been treated with Ph3Sb(OPri)2 to yield Ph3Sb[SC6H4NC(C6H5)CH:CO︹COOCH3] 2. These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (H1 and C13) spectral evidences. Both compounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds 1 and 2 at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by 36.57%; 57.23%, pachytene spermatocytes by 40.06%; 62.01%, and secondary spermatocytes by 52.45%; 63.22%, following the treatment of compounds 1 and 2, respectively. The marked reduction in sperm motility and density resulted in infertility by 100%. Significant (P<.01) alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

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Copyright © 2006 D. Shanker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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