DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions

<table>Comparison of the DNA cleavage intensity in the case of both Cu(II) and Fe(II) complexes with the studied compounds in the presence of ascorbate (ASC). Lane 1, untreated DNA; lane 2, DNA + ASC; lane 3, DNA + Cu(II) + ASC; lane 4, DNA + Fe(II) + ASC; lane 5, DNA + DFQa-Gly + ASC; lane 6, DNA + Cu–DFQa-Gly + ASC; lane 7, DNA + Fe–DFQa-Gly + ASC; lane 8, DNA + DPPZa-Gly + ASC; lane 9, DNA + Cu–DPPZa-Gly + ASC; lane 10, DNA + Fe–DPPZa-Gly + ASC; lane 11, DNA + DPQa-Gly + ASC; lane 12, DNA + Cu–DPQa-Gly + ASC; lane 13, DNA + Fe–DPQa-Gly + ASC.</table>

Bioinorganic Chemistry and Applications

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Figure 8

Figure 8: DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions 