Synthesis and Biological Evaluation of New CRH Analogues

Figure 1

(a) Analytical HPLC chromatogram of crude analogue [D-Phe¹², Cys(Pr)²¹, Cys(Pr)³⁸]CRH previously chromatographed on a semipreparative C18 column. (b) Analytical HPLC chromatogram of analogue [D-Phe¹², Cys(Pr)²¹, Cys(Pr)³⁸]CRH upon rechromatography on the same column. (c) Mass spectra of analogue [D-Phe¹², Cys(Pr)²¹, Cys(Pr)³⁸]CRH resulting from ESI-MS analysis [MW_calc=4785.58; (M+4)_obs⁴⁺/4=1198.2; (M+3)_obs³⁺/3=1596.5].

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