DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes

<table>The molar Gibbs free energies of unfolding (<svg height="13.225" id="M49" style="vertical-align:-0.23206pt" version="1.1" viewbox="0 0 28.362499 13.225" width="28.362499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.012,-0,0,-.012,23.262,4.712)"><path d="M326 255q0 -56 -41 -96t-99 -40t-99 40t-41 96t41 96t99 40t99 -40t41 -96zM274 255q0 38 -25.5 65t-62.5 27t-62.5 -27t-25.5 -65t25.5 -65t62.5 -27t62.5 27t25.5 65z" id="x2218"></path></g>
</svg> versus [<i>L</i>]<sub>t</sub>) of CT-DNA in the presence of [Pt(bpy)(Oct-dtc)]NO<sub>3</sub> and the inset for [Pd(bpy)(Oct-dtc)]NO<sub>3</sub>.</table>

Bioinorganic Chemistry and Applications

fig3

Figure 3

Figure 3: DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes 