Synthesis, Characterization, and Antibacterial Studies of Pd(II) and Pt(II) Complexes of Some Diaminopyrimidine Derivatives

Table 3

MIC values (mg/mL) of the metal complexes on selected bacteria.

Complexes	E. coli	P. aeruginosa	S. aureus	S. faecalis	B. cereus	B. pumilus	K. pneumonia	P. vulgaris
[Pd(pyrm)2Cl2]	NI	5.0	0.63	NI	NI	0.63	0.31	NI
[Pd(pyrm)2(NCS)2]	NI	5.0	0.31	NI	NI	0.63	0.63	NI
[Pt(pyrm)2Cl2]	20.0	NI	10.0	5.0	NI	NI	NI	NI
[Pt(pyrm)2(NCS)2]	10.0	NI	10.0	NI	5.0	NI	NI	5.0
[Pd(tmp)2Cl2]	20.0	NI	10.0	NI	5.0	NI	5.0	10.0
[Pd(tmp)2(NCS)2]	10.0	NI	NI	10.0	NI	NI	NI	NI
[Pt(tmp)2Cl2]	20.0	NI	10.0	NI	10.0	NI	5.0	10.0
[Pt(tmp)2(NCS)2]	20.0	NI	10.0	NI	10.0	NI	NI	5.0
Pyrimethamine	20.0	NA	20.0	20.0	10.0	NA	20.0	10.0
Trimethoprim	20.0	NA	10.0	20.0	10.0	NA	10.0	10.0