Synthesis and Characterization with Antineoplastic, Biochemical, Cytotoxic, and Antimicrobial Studies of Schiff Base Cu(II) Ion Complexes

Table 4

The effect of test compounds and bleomycin on EAC cell growth inhibition.

Experiment	Drugs	Dose	Number of EAC cells/mouse on 5th day after tumour (EAC) cell inoculation	% of cell growth inhibition
EAC			(9.61 ± 1.63) × 10^7
EAC + bleomycin		0.3 mg/kg	(0.49 ± 0.77) × 10^7	94.90
A	Synthetic	8 mg/kg	(0.46 ± 0.62) × 10^7	95.21
B	Synthetic	10 mg/kg	(1.21 ± 0.32) × 10^7	87.40
C	Synthetic	16 mg/kg	(1.01 ± 0.78) × 10^7	89.49

A = K[Cu(SB-1)(SCN)], B = [Cu(SB-2)NN], NN = 2-aminopyridine, and C = [Cu(SB-2)(NN)], NN = 2-phenylenediamine.