Synthesis and Characterization with Antineoplastic, Biochemical, Cytotoxic, and Antimicrobial Studies of Schiff Base Cu(II) Ion Complexes

Table 6

The effect of test compounds on survival time of EAC cell bearing mice.

Days	Control (EAC)	Bleomycin; (0.3 mg/kg i.p.)	DMSO; 25 mg/kg	A; 8 mg/kg	B; 10 mg/kg	C; 16 mg/kg
0	00	00	00	00	00	00
2	0.77 ± 0.37	0.57 ± 0.17	0.76 ± 0.38	0.55 ± 0.13	0.64 ± 0.19	0.60 ± 0.26
4	0.98 ± 0.43	0.75 ± 0.22	0.97 ± 0.63	0.72 ± 0.22	0.84 ± 0.24	0.82 ± 0.17
6	1.30 ± 0.27	1.10 ± 0.24	1.31 ± 0.33	1.06 ± 0.24	1.21 ± 0.16	1.16 ± 0.31
8	1.54 ± 0.32	1.24 ± 0.14	1.57 ± 0.23	1.14 ± 0.12	1.37 ± 0.16	1.31 ± 0.14
10	1.78 ± 0.18	1.44 ± 0.30	1.76 ± 0.16	1.29 ± 0.19	1.48 ± 0.26	1.43 ± 0.22
12	2.13 ± 0.17	1.63 ± 0.16	2.14 ± 0.17	1.47 ± 0.22	1.77 ± 0.18	1.71 ± 0.14
14	2.55 ± 0.67	1.80 ± 0.23	2.55 ± 0.63	1.73 ± 0.32	1.93 ± 0.34	1.84 ± 0.18
16	3.94 ± 0.55	2.05 ± 0.27	3.93 ± 0.53	1.94 ± 0.14	2.17 ± 0.12	2.10 ± 0.21
18	4.44 ± 0.43	2.20 ± 0.15	4.40 ± 0.42	2.13 ± 0.12	2.47 ± 0.15	2.29 ± 0.23
20	5.13 ± 0.63	2.43 ± 0.11	5.14 ± 0.62	2.36 ± 0.16	2.73	2.49 ± 0.44

A = K[Cu(SB-1)(SCN)], B = [Cu(SB-2)NN], NN = 2-aminopyridine, and C = [Cu(SB-2)(NN)], NN = 2-phenylenediamine.