Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

Figure 5

In vivo animal model for peripheral nerve injury on the sciatic nerve (a). A healthy sciatic nerve after surgical splitting of the muscles (b). Application of the Yasargil aneurism clip for trauma on the sciatic nerve (c). The sciatic nerve injury site after removal of the Yasargil aneurism clip (d). Implantation of composite nanofibers around the injured sciatic nerve just after the trauma (e). Scanning electron microscopy images of (e). Composite nanofibers containing ALA- and ATR-loaded chitosan nanoparticles (f). ATR-loaded chitosan nanoparticles existing in the composite nanofiber structure; reproduced with permission from [44].