Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses

Figure 9

DBDCT-induced apoptosis via Gal-1-mediated pathway. (a) Western blot and relative protein levels of Bax, Bcl-2, and P53 with DBDCT at different concentrations for 24 h. (b) Western blot and relative protein levels of Bax and Bcl-2 with DBDCT (3 μmol/L) for different time. (c) Relative mRNA levels of Bax and Bcl-2. HL7702 liver cells were treated with DBDCT or exposed to OTX008 for 3 h firstly and then treated with or without DBDCT. Each value represents the mean ± SD of three independent experiments. compared with the control. , , and compared with the DBDCT alone.

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