Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses

Table 2

Regulated proteins related to apoptosis identified by LC-MS/MS and UniProt database.

Protein ID	Protein name	Gene name	Fold change	Expression change
P11762^a	Galectin-1	Lgals1	17.96	Increase
P10361^a	Cellular tumor antigen p53	Tp53	10.51	Increase
Q63690^a	Apoptosis regulator BAX	Bax	4.93	Increase
Q63199^a	Tumor necrosis factor receptor superfamily member 6	Fas	4.80	Increase
P55213^a	Caspase-3	Casp3	12.39	Increase
Q920G4^a	Caspase-9	Casp9	6.06	Increase
P63086	Mitogen-activated protein kinase 1	Mapk1	0.14	Decrease
P20171^a	GTPase HRas	Hras	0.08	Decrease
Q32PX2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	Aimp2	0.46	Decrease
Q9JLH7	CDK5 regulatory subunit-associated protein 3	Cdk5rap3	0.41	Decrease
P35213-2	14-3-3 protein beta/alpha	Ywhab	0.42	Decrease
Q07014-2	Tyrosine-protein kinase Lyn	Lyn	0.45	Decrease
P49950^a	Apoptosis regulator Bcl-2	Bcl2	0.06	Decrease
Q4G009	Malignant T-cell-amplified sequence 1	Mcts1	0.32	Decrease
Q9JID1	Programmed cell death protein 4	Pdcd4	0.46	Decrease

Note. The differential proteins labeled ^a are the proteins that have been subsequently verified.