Synthesis and Optimization of Deesterified Acacia-Alginate Nanohydrogel for Amethopterin Delivery

Table 4

Signal-to-noise ratio for particle size responses with respect to process parameters and their levels, the smaller the better.

Level	DEA solution concentration (w/v %)	Alginate molecular weight (MW)	ATN/DEA ratio (w/w %)
1	−45.59	−49.53	−47.44
2	−49.82	−49.74	−48.70
3	−49.14	−47.87	−51.27
4	−51.72	−49.12	−48.86
Delta	6.13	1.87	3.83
Rank	1	3	2