[Retracted] 5-Fluorouracil-Loaded PLGA Nanoparticles: Formulation, Physicochemical Characterisation, and In VitroAnti-Cancer Activity

Table 1

Lists of the physical and chemical properties of several NP preparation made either with or without, i.e., blank FU (B-PLGA-NPs) (FU-PLGA-NPs).

Parameters	B-PLGA-NPs	FU-PLGA-NPs	B-PLGA-NPs	FU-PLGA-NPs	B-PLGA-NPs	FU-PLGA-NPs
Polymer	RRG502H		RRG502		RRG755
MW	6000		14,500		63,600
Ratio GA/LA	50/50		50/50		25/75
PS (nm)	121 ± 5	127 ± 7	142 ± 4	142 ± 3	166 ± 5	174 ± 4
PDI	0.08 ± 0.04	0.06 ± 0.04	0.2 ± 0.04	0.12 ± 0.04	0.06 ± 0.04	0.09 ± 0.06
EM (µm·cm/V.S)	−23.53 ± 0.6	−23.84 ± 0.7	−24.7 ± 0.3	−21.0 ± 0.6	−22.37 ± 0.7	−25.5 ± 0.6
ZP (mV)	−31.4 ± 5.7	−35 ± 7.8	−34.8 ± 3.5	−26.4 ± 4.2	−24.6 ± 4.6	−24.7 ± 4.1

After the various formulations were properly diluted, DELSA was used to calculate the ZP and electrophoretic mobility (EM) of the samples, and PCS was used to quantify PS diameter and polydispersity index (PDI). The FU-PLGA-NPs were formulated using technique II, with a 1% (w/w) initial drug loading.