Effect of Oxysterol-Induced Apoptosis of Vascular Smooth Muscle Cells on Experimental Hypercholesterolemia

Table 3

Bcl-2/Bax and Bcl-xl/Bax expression ratios in SMC cultures: Bcl-2/Bax and Bcl-xl/Bax expression ratios in SMC cultures at baseline (SMC-C, SMC-Ch, and SMC-Ch-FO) and Bcl-2/Bax and Bcl-xl/Bax Expression ratios for SMC cultures treated with 20 μg/ml 25-hydroxycholesterol for 24 hours. Ratios were calculated by using O.D protein and reading and normalized against a control (SMC-C) for each protein. Each datum indicated mean  ± SEM of three independent experiments. *P < .05, ^**P < .01, ^***P < .001 versus SMC-C.

	Bcl-XL/Bax	Bcl-2/Bax
SMC-C	1	1
SMC-Ch	1.3*	0.97
SMC-Ch-FO	1.7^**	1.13
25-Hydroxycholesterol 20 𝜇g/ml	Bcl-XL/Bax	Bcl-2/Bax
SMC-C	0.77	0.56^***
SMC-Ch	0.99	0.61^**
SMC-Ch-FO	0.82^**	0.61^**