MIClique: An Algorithm to Identify Differentially Coexpressed Disease Gene Subset from Microarray Data

Table 4

GO annotations of eight DEC genes identified from colon dataset by MIClique.

Gene Symbol	Ontology	GO Terms
DESMIN	Biological process	Cytoskeleton organization; muscle contraction; regulation of heart contraction
	Cellular component	Z disc
	Molecular function	Protein binding; structural constituent of cytoskeleton
CD37	Biological process	Protein amino acid N-linked glycosylation
	Cellular component	Plasma membrane; integral to plasma membrane
MYH9	Biological process	Actin cytoskeleton reorganization; actin filament-based movement; angiogenesis; blood vessel endothelial cell migration; cytokinesis; membrane protein ectodomain proteolysis; monocyte differentiation; platelet formation; protein transport; regulation of cell shape
	Cellular component	Cleavage furrow; contractile ring; cytoplasm; cytosol; integrin complex; nucleus; plasma membrane; ruffle; stress fiber
	Molecular function	Actin filament binding; ATPase activity; microfilament motor activity; protein anchor; protein homodimerization activity
TPM2	Biological process	Regulation of ATPase activity
	Cellular component	Muscle thin filament tropomyosin
	Molecular function	Actin binding; structural constituent of muscle
ITGA7	Biological process	Cell-matrix adhesion; muscle organ development; integrin-mediated signaling pathway
	Molecular function	Calcium ion binding; protein binding; receptor activity
MYL2	Biological process	Cardiac myofibril assembly; heart contraction; negative regulation of cell growth; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis
	Cellular component	Sarcomere
	Molecular function	Actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle
SPARCL1	Biological process	Signal transduction
	Molecular function	Calcium ion binding
ZEB1	Biological process	Cell proliferation; immune response; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
	Molecular function	Transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding